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1. Stavudine (Zerit) is an antiviral agent employed in the treatment of
A.
B.
C.
D.
E.

2. Zafirlukast (Accolate) is a drug that can best be classified as a (an)
A.
B.
C.
D.
E.

3. Deferoxamine mesylate (Desferal) is considered to be a specific antidote for the treatment of poisoning caused by
A.
B.
C.
D.
E.

4. Which of the following agents is (are) classified as antiseptics or germicides?
I. chlorhexidine gluconate (Hibiclens)
II. glutaraldehyde (Cidex)
III. benzalkonium chloride (Zephiran)
A.
B.
C.
D.
E.

5. In monitoring a patient receiving warfarin for the treatment of acute myocardial infarction, it is important to maintain the INR between
A.
B.
C.
D.
E.

6. The pharmacological properties of which one of the following agents is similar to amphetamine?
A.
B.
C.
D.
E.

7. Endorphins are
A.
B.
C.
D.
E.

8. Which one of the following is an effect of atropine on the human body?
A.
B.
C.
D.
E.

9. Prolonged use of organic nitrates (eg, nitroglycerin) is likely to result in the development of
A.
B.
C.
D.
E.

10. Benzoyl peroxide is commonly employed in the treatment of
A.
B.
C.
D.
E.

11. Which of the following is (are) true of ticlopidine HCl (Ticlid)?
I. inhibits platelet aggregation
II. dissolves blood clots
III. only administered parenterally
A.
B.
C.
D.
E.

12. A disadvantage in the use of cimetidine (Tagamet) is its ability to cause
A.
B.
C.
D.
E.

13. Potassium depletion is LEAST likely to occur in a patient using
A.
B.
C.
D.
E.

14. Propylthiouracil is used for the same therapeutic indication as
A.
B.
C.
D.
E.

15. The primary function of simethicone in antacid products is to act as a (an)
A.
B.
C.
D.
E.

16. Which of the following antianxiety agents causes the least sedation?
A.
B.
C.
D.
E.

17. Dalteparin sodium (Fragmin) acts in the body to
A.
B.
C.
D.
E.

18. Which one of the following antihistamines would be LEAST likely to cause sedation?
A.
B.
C.
D.
E.

19. Which of the following antimicrobial products is (are) prodrugs?
I. cefpodoxime proxetil
II. dirithromycin
III. clindamycin
A.
B.
C.
D.
E.

20. Which of the following is an active metabolite of primidone (Mysoline)?
I. acetylcholine
II. phenylethylmalonamide
III. phenobarbital
A.
B.
C.
D.
E.

21. Which of the following beta-adrenergic blocking agents also exhibit alpha1-adrenergic blocking action?
I. timolol (Blocadren)
II. sotalol (Betapace)
III. labetalol (Normodyne, Trandate)
A.
B.
C.
D.
E.

22. Metoclopramide (Reglan) is most similar in action to which of the following drugs?
A.
B.
C.
D.
E.

23. Cyclophosphamide (Cytoxan) is an example of a (an)
A.
B.
C.
D.
E.

24. Repaglinide (Prandin) is believed to work by
A.
B.
C.
D.
E.

25. The most serious potential consequence of ingestion of a liquid hydrocarbon such as kerosene or gasoline is
A.
B.
C.
D.
E.

26. Haloperidol (Haldol) differs from chlorpromazine (Thorazine) in that haloperidol
A.
B.
C.
D.
E.

27. Which of the following is a gold compound?
I. aurothioglucose (Solganal)
II. goserelin acetate (Zoladex)
III. ergonovine
A.
B.
C.
D.
E.

28. Lactulose is used to treat
I. constipation
II. portal-systemic encephalopathy
III. renal tubular necrosis
A.
B.
C.
D.
E.

29. Which of the following drugs may interfere with ethanol metabolism?
I. metronidazole (Flagyl)
II. chlorpropamide (Diabinese)
III. disulfiram (Antabuse)
A.
B.
C.
D.
E.

30. The renal excretion of amphetamines can be diminished by alkalinization of the urine. Which of the following would tend to diminish the excretion rate of amphetamine sulfate?
I. methenamine mandelate
II. acetazolamide
III. sodium bicarbonate
A.
B.
C.
D.
E.

31. The agent most similar in pharmacological action to miglitol (Glyset) is
A.
B.
C.
D.
E.

32. Which of the following cancer chemotherapeutic agents is (are) classified as an antimetabolite?
I. mercaptopurine (Purinethol)
II. fluorouracil (Adrucil)
III. cytarabine (Cytosar-U)
A.
B.
C.
D.
E.

33. Which of the following statements is (are) true of fentanyl?
I. It is a narcotic agonist analgesic.
II. It is available as a transmucosal system.
III. It is available as a transdermal system.
A.
B.
C.
D.
E.

34. Which of the following is a COMT inhibitor?
A.
B.
C.
D.
E.

35. Methadone (Dolophine) is a (an)
I. analgesic drug
II. controlled substance
III. narcotic antagonist
A.
B.
C.
D.
E.

36. Which of the following is (are) true of sim-vastatin (Zocor)?
I. HMG-CoA reductase inhibitor
II. pregnancy category X
III. antiviral
A.
B.
C.
D.
E.

37. Alteplase (Activase) is employed clinically as a (an)
A.
B.
C.
D.
E.

38. Aspirin is believed to inhibit clotting by its action on which of the following endogenous substances?
A.
B.
C.
D.
E.

39. Thiazide diuretics decrease the excretion of
A.
B.
C.
D.
E.

40. The dose of liothyronine sodium that is approximately equivalent to 100 ).!g of levothyroxine sodium (Synthroid) USP is
A.
B.
C.
D.
E.

41. Which one of the following statements best describes the mechanism of action of ranitidine (Zantac)?
A.
B.
C.
D.
E.

42. Which of the following drugs is (are) sulfonamides?
A.
B.
C.
D.
E.

43. Iron is required by the body to maintain normal
A.
B.
C.
D.
E.

44. The thiazide derivative diazoxide (Hyperstat)
A.
B.
C.
D.
E.

45. Which of the following hormones is released from the posterior pituitary gland?
I. growth hormone
II. follicle-stimulating hormone (FSH)
III. oxytocin
A.
B.
C.
D.
E.

46. Which of the following drugs is (are) classified as a selective serotonin reuptake inhibitor (SSRI)?
I. citalopram (Celexa)
II. sertraline (Zoloft)
III. venlafaxine (Effexor)
A.
B.
C.
D.
E.

47. Gingival hyperplasia, hirsutism, and ataxia are adverse effects associated with the use of
A.
B.
C.
D.
E.

48. Hypoparathyroidism is a disorder that would most logically be treated with
A.
B.
C.
D.
E.

49. Which of the following is (are) true of milrinone lactate (Primacor)?
I. may be administered orally or parenterally
II. produces a positive inotropic action
III. produces vasodilation
A.
B.
C.
D.
E.

50. Didofenac sodium (Voltaren) is most similar in action to
A.
B.
C.
D.
E.

51. The anti-inflammatory effect of NSAIDs is due to their ability to
1. inhibit prostaglandin synthesis
II. inhibit the stimulation of the chemoreceptor trigger zone (CTZ)
III. reset the hypothalamic "setpoint"
A.
B.
C.
D.
E.

52. Which of the following morphine derivatives is most likely to cause dependence?
A.
B.
C.
D.
E.

53. Which of the following bronchodilators act by inhibiting phosphodiesterase?
I. dyphylline (Lufyllin)
II. salmeterol (Serevent)
III. nedocromil sodium (Tilade)
A.
B.
C.
D.
E.

54. Amrinone (Inocor) is a drug that produces
A.
B.
C.
D.
E.

55. Which of the following is (are) classified as aminopenicillins?
I. bacampicillin
II. amoxicillin
III. ampicillin
A.
B.
C.
D.
E.

56. Which of the following agents is (are) indicated for the treatment of chronic inflammatory bowel disease?
A.
B.
C.
D.
E.

57. Which of the following statements is (are) true of "crack"?
I. It is a free-base form of cocaine.
II. Its use results in eNS depression.
III. It is generally injected intravenously.
A.
B.
C.
D.
E.

58. Which one of the following drugs is employed in treating acute attacks of gout?
A.
B.
C.
D.
E.

59. Most antipsychotic drugs can be said to have which of the following actions?
A.
B.
C.
D.
E.

60. Prolonged activity (8 to 10 hours) is an advantage in the use of which of the following topical decongestants?
I. phenylephrine
II. oxymetazoline
III. xylometazoline
A.
B.
C.
D.
E.