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1. The anti-inflammatory effect of NSAIDs is due to their ability to
1. inhibit prostaglandin synthesis
II. inhibit the stimulation of the chemoreceptor trigger zone (CTZ)
III. reset the hypothalamic "setpoint"
A.
B.
C.
D.
E.

2. Which of the following statements is (are) true of "crack"?
I. It is a free-base form of cocaine.
II. Its use results in eNS depression.
III. It is generally injected intravenously.
A.
B.
C.
D.
E.

3. Which of the following cancer chemotherapeutic agents is (are) classified as an antimetabolite?
I. mercaptopurine (Purinethol)
II. fluorouracil (Adrucil)
III. cytarabine (Cytosar-U)
A.
B.
C.
D.
E.

4. Which of the following is true of pilocarpine (Isopto Carpine, Pilostat)?
I. similar pharmacologic action to dorzolamide (Trusopt)
II. direct-acting mydriatic
III. ingredient in Ocusert ocular therapeutic system
A.
B.
C.
D.
E.

5. In the treatment of cardiac arrhythmias, sotalol (Betapace) is most similar in action to
A.
B.
C.
D.
E.

6. Which of the following morphine derivatives is most likely to cause dependence?
A.
B.
C.
D.
E.

7. Dalteparin sodium (Fragmin) acts in the body to
A.
B.
C.
D.
E.

8. Which of the following is a gold compound?
I. aurothioglucose (Solganal)
II. goserelin acetate (Zoladex)
III. ergonovine
A.
B.
C.
D.
E.

9. Which of the following agents is (are) classified pharmacologically as carbonic anhydrase inhibitors?
I. fluvastatin
II. nitroprusside
III. acetazolamide
A.
B.
C.
D.
E.

10. Which of the following agents is (are) used for the treatment of migraine headaches?
I. rizatriptan benzoate
II. methysergide maleate
III. succinylcholine chloride
A.
B.
C.
D.
E.

11. Which of the following agents is (are) used as anorexiants?
I. sibutramine (Meridia)
II. mazindol (Sanorex, Mazanor)
III. benzphetamine (Didrex)
A.
B.
C.
D.
E.

12. Which of the following is true of naratriptan (Amerge)?
I. It is a 5-HT1-receptor antagonist.
II. It may be administered orally or by inhalation.
III. It must be used regularly to prevent migraine headaches.
A.
B.
C.
D.
E.

13. Sulfonamides exert their antimicrobial effect by competitively inhibiting the action of
A.
B.
C.
D.
E.

14. Which of the following beta-adrenergic blocking agents is beta1-selective?
I. betaxolol (Betoptic)
II. metipranolol HCl (OptiPranolol)
III. timolol (Timoptic)
A.
B.
C.
D.
E.

15. Which one of the following barbiturates is likely to be the shortest acting?
A.
B.
C.
D.
E.

16. Clonidine may best be described as a (an)
A.
B.
C.
D.
E.

17. Although classified as antibiotics, dactinomycin (Cosmegen) and plicamycin (Mithracin) are used in cancer chemotherapy because they have a (an)
A.
B.
C.
D.
E.

18. Three hundred milligrams of phenoxymethyl penicillin is equivalent to approximately how many units of penicillin activity?
A.
B.
C.
D.
E.

19. Which of the following is (are) true of ticlopidine HCl (Ticlid)?
I. inhibits platelet aggregation
II. dissolves blood clots
III. only administered parenterally
A.
B.
C.
D.
E.

20. Which of the following beta-adrenergic blocking agents also exhibit alpha1-adrenergic blocking action?
I. timolol (Blocadren)
II. sotalol (Betapace)
III. labetalol (Normodyne, Trandate)
A.
B.
C.
D.
E.

21. Which of the following are employed clinically as intranasal steroids?
I. budesonide (Rhinocort)
II. fluticasone propionate (Flonase)
III. nedocromil (Tilade)
A.
B.
C.
D.
E.

22. Trifluridine is useful in the treatment of epithelial keratitis caused by
A.
B.
C.
D.
E.

23. As an antiarrhythmic drug, tocainide is most similar in action to which one of the following agents?
A.
B.
C.
D.
E.

24. Which of the following antimicrobial products is (are) prodrugs?
I. cefpodoxime proxetil
II. dirithromycin
III. clindamycin
A.
B.
C.
D.
E.

25. Metoclopramide (Reglan) is most similar in action to which of the following drugs?
A.
B.
C.
D.
E.

26. After oral administration, the greatest amount of iron absorption occurs in the
A.
B.
C.
D.
E.

27. Didanosine (Videx) can best be described as a (an)
A.
B.
C.
D.
E.

28. Which of the following is (are) true of finasteride (Proscar, Propecia)?
I. pregnancy category X
II. employed in the treatment of BPH
III. used in alopecia treatment
A.
B.
C.
D.
E.

29. Which one of the following statements best describes the mechanism of action of ranitidine (Zantac)?
A.
B.
C.
D.
E.

30. Which one of the following drugs is employed in treating acute attacks of gout?
A.
B.
C.
D.
E.

31. Which of the following statements is (are) true of potassium?
I. It is a divalent cation.
II. It facilitates the utilization of glucose by cells.
III. It is the principal intracellular ion.
A.
B.
C.
D.
E.

32. Benzoyl peroxide is commonly employed in the treatment of
A.
B.
C.
D.
E.

33. Gastric intrinsic factor is a glycoprotein that is required for the gastrointestinal absorption of
A.
B.
C.
D.
E.

34. A disadvantage in the use of cimetidine (Tagamet) is its ability to cause
A.
B.
C.
D.
E.

35. A common adverse effect associated with the chronic use of magnesium antacids is
A.
B.
C.
D.
E.

36. Which of the following agents have cortical stimulant action?
I. buspirone
II. pemoline
III. methamphetamine
A.
B.
C.
D.
E.

37. Which of the following hormones is released from the posterior pituitary gland?
I. growth hormone
II. follicle-stimulating hormone (FSH)
III. oxytocin
A.
B.
C.
D.
E.

38. Carbidopa can best be classified as a drug that
A.
B.
C.
D.
E.

39. Which of the following drugs are available in a transdermal form for the prevention of motion sickness?
A.
B.
C.
D.
E.

40. Cromolyn sodium (Intal, Nasalcrom, Opticrom) is a drug that is
A.
B.
C.
D.
E.

41. Deferoxamine mesylate (Desferal) is considered to be a specific antidote for the treatment of poisoning caused by
A.
B.
C.
D.
E.

42. Which of the following bronchodilators act by inhibiting phosphodiesterase?
I. dyphylline (Lufyllin)
II. salmeterol (Serevent)
III. nedocromil sodium (Tilade)
A.
B.
C.
D.
E.

43. Danazol (Danocrine) can best be classified as a (an)
A.
B.
C.
D.
E.

44. Ramipril HCl (Altace) can best be classified as a (an)
A.
B.
C.
D.
E.

45. Sulfones such as dapsone are employed commonly in the treatment of
A.
B.
C.
D.
E.

46. Haloperidol (Haldol) differs from chlorpromazine (Thorazine) in that haloperidol
A.
B.
C.
D.
E.

47. The renal excretion of amphetamines can be diminished by alkalinization of the urine. Which of the following would tend to diminish the excretion rate of amphetamine sulfate?
I. methenamine mandelate
II. acetazolamide
III. sodium bicarbonate
A.
B.
C.
D.
E.

48. Lactase enzyme is available for the treatment of
A.
B.
C.
D.
E.

49. Which of the following is (are) true of fentanyl?
I. available as a transdermal system
II. used as a local anesthetic
III. may be used as a cough suppressant
A.
B.
C.
D.
E.

50. The pharmacological properties of which one of the following agents is similar to amphetamine?
A.
B.
C.
D.
E.

51. Phosphate binding is likely to occur when which of the following antacids are administered?
I. aluminum hydroxide
II. sodium bicarbonate
III. calcium carbonate
A.
B.
C.
D.
E.

52. Which of the following can be classified as an osmotic laxative?
A.
B.
C.
D.
E.

53. Which of the following is a COMT inhibitor?
A.
B.
C.
D.
E.

54. Most antipsychotic drugs can be said to have which of the following actions?
A.
B.
C.
D.
E.

55. Beta carotene is considered to be a precursor for
A.
B.
C.
D.
E.

56. Which of the following drugs is (are) classified as a selective serotonin reuptake inhibitor (SSRI)?
I. citalopram (Celexa)
II. sertraline (Zoloft)
III. venlafaxine (Effexor)
A.
B.
C.
D.
E.

57. Which one of the following is NOT a progestin?
A.
B.
C.
D.
E.

58. Which of the following agents is (are) classified as a leukotriene receptor antagonist?
I. ipratropium bromide
II. zileuton
III. montelukast sodium
A.
B.
C.
D.
E.

59. Of the following glucocorticoids, which one has the greatest anti-inflammatory potency when administered systemically?
A.
B.
C.
D.
E.

60. Alteplase (Activase) is an example of a tissue plasminogen activator. Which of the following describes the characteristics of this drug?
I. administered orally
II. stimulates erythrocyte production
III. produced by recombinant DNA technology
A.
B.
C.
D.
E.