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1. Prednisone is an agent that is employed in the treatment of
I. fungal infections
II. Crohn's disease
III. rheumatic disorders
A.
B.
C.
D.
E.

2. Metoclopramide (Reglan) is most similar in action to which of the following drugs?
A.
B.
C.
D.
E.

3. Danazol (Danocrine) can best be classified as a (an)
A.
B.
C.
D.
E.

4. Which of the following drugs may be used in the treatment of diabetes insipidus?
A.
B.
C.
D.
E.

5. Which of the following statements is (are) TRUE of buprenorphine (Buprenex)?
I. It is a narcotic agonist-antagonist drug.
II. It is only administered parenterally.
III. It is a phenothiazine derivative.
A.
B.
C.
D.
E.

6. Which of the following is (are) employed as an antifungal agent?
I. cycloserine
II. mafenide
III. terbinafine
A.
B.
C.
D.
E.

7. The primary site of action of triamterene (Dyrenium) and spironolactone (Aldactone) is the
A.
B.
C.
D.
E.

8. Finasteride (Proscar, Propecia) can best be described as a (an)
A.
B.
C.
D.
E.

9. Which of the following morphine derivatives is most likely to cause dependence?
A.
B.
C.
D.
E.

10. Reflex tachycardia is an adverse effect most likely to be associated with the use of which of the following drugs?
A.
B.
C.
D.
E.

11. Ramipril HCl (Altace) can best be classified as a (an)
A.
B.
C.
D.
E.

12. Fluvastatin (Lescol) is contraindicated for use in patients who are
A.
B.
C.
D.
E.

13. Reduced clotting ability of the blood is associated with the administration of
I. clopidogrel (Plavix)
II. abciximab (ReoPro)
III. filgrastim (Neupogen)
A.
B.
C.
D.
E.

14. Amrinone (Inocor) is most similar in action to
A.
B.
C.
D.
E.

15. Carbon monoxide exerts its toxic effects primarilyby
A.
B.
C.
D.
E.

16. Effects expected as a result of inhaling the smoke of cannabis (marijuana) include
I. decreased pulse rate
II. perceptual changes
III. vascular congestion of the eye
A.
B.
C.
D.
E.

17. Which of the following antiarrhythmic agents is (are) associated with an adverse effect known as cinchonism?
A.
B.
C.
D.
E.

18. The anti-inflammatory effect of NSAIDs is due to their ability to
1. inhibit prostaglandin synthesis
II. inhibit the stimulation of the chemoreceptor trigger zone (CTZ)
III. reset the hypothalamic "setpoint"
A.
B.
C.
D.
E.

19. Which one of the following drugs is employed in treating acute attacks of gout?
A.
B.
C.
D.
E.

20. Which of the following is (are) true of milrinone lactate (Primacor)?
I. may be administered orally or parenterally
II. produces a positive inotropic action
III. produces vasodilation
A.
B.
C.
D.
E.

21. Isotretinoin (Accutane) is a drug employed in the treatment of severe recalcitrant cystic acne. Which one of the following is NOT an adverse effect associated with its use?
A.
B.
C.
D.
E.

22. Which of the following agents are classified as macrolides?
I. amikacin
II. polymyxin B
III. azithromycin
A.
B.
C.
D.
E.

23. Which of the following drugs is (are) sulfonamides?
A.
B.
C.
D.
E.

24. Which of the following agents have cortical stimulant action?
I. buspirone
II. pemoline
III. methamphetamine
A.
B.
C.
D.
E.

25. Which of the following drugs is (are) H1-histamine receptor antagonists?
I. diphenhydramine
II. hydroxyzine
III. famotidine
A.
B.
C.
D.
E.

26. Alteplase (Activase) is an example of a tissue plasminogen activator. Which of the following describes the characteristics of this drug?
I. administered orally
II. stimulates erythrocyte production
III. produced by recombinant DNA technology
A.
B.
C.
D.
E.

27. Which one of the following is an effect of atropine on the human body?
A.
B.
C.
D.
E.

28. Which one of the following drugs is indicated for the treatment of primary nocturnal enuresis?
A.
B.
C.
D.
E.

29. Which one of the following agents can be administered with ampicillin and other penicillins to achieve higher blood levels of the penicillin?
A.
B.
C.
D.
E.

30. The agent most similar in pharmacological action to miglitol (Glyset) is
A.
B.
C.
D.
E.

31. Which of the following statements is (are) true of "crack"?
I. It is a free-base form of cocaine.
II. Its use results in eNS depression.
III. It is generally injected intravenously.
A.
B.
C.
D.
E.

32. Gastric intrinsic factor is a glycoprotein that is required for the gastrointestinal absorption of
A.
B.
C.
D.
E.

33. The dose of liothyronine sodium that is approximately equivalent to 100 ).!g of levothyroxine sodium (Synthroid) USP is
A.
B.
C.
D.
E.

34. Drugs employed in reducing elevated serum cholesterol include(s)
I. gemfibrozil (Lopid)
II. cerivastatin (Baycol)
III. pioglitazone (Aetos)
A.
B.
C.
D.
E.

35. Which of the following is true of permethrin (Nix, Elimite)?
I. It is only used topically.
II. It is used to treat topical fungal infections.
III. It is used to enhance permeation of drugs through the skin.
A.
B.
C.
D.
E.

36. Benzoyl peroxide is commonly employed in the treatment of
A.
B.
C.
D.
E.

37. Which of the following is (are) true of fentanyl?
I. available as a transdermal system
II. used as a local anesthetic
III. may be used as a cough suppressant
A.
B.
C.
D.
E.

38. Prolonged activity (8 to 10 hours) is an advantage in the use of which of the following topical decongestants?
I. phenylephrine
II. oxymetazoline
III. xylometazoline
A.
B.
C.
D.
E.

39. Which one of the following agents is most similar in action to cloxacillin?
A.
B.
C.
D.
E.

40. Which of the following agents is (are) indicated for use in the treatment of emesis?
I. dronabinol (Marinol)
II. granisetron (Kytril)
III. nalbumetone (Relafen)
A.
B.
C.
D.
E.

41. Which one of the following antihistamines would be LEAST likely to cause sedation?
A.
B.
C.
D.
E.

42. A uricosuric drug is one that
A.
B.
C.
D.
E.

43. Endorphins are
A.
B.
C.
D.
E.

44. A disadvantage in the use of cimetidine (Tagamet) is its ability to cause
A.
B.
C.
D.
E.

45. Which of the following bronchodilators act by inhibiting phosphodiesterase?
I. dyphylline (Lufyllin)
II. salmeterol (Serevent)
III. nedocromil sodium (Tilade)
A.
B.
C.
D.
E.

46. Gingival hyperplasia, hirsutism, and ataxia are adverse effects associated with the use of
A.
B.
C.
D.
E.

47. Aspirin is believed to inhibit clotting by its action on which of the following endogenous substances?
A.
B.
C.
D.
E.

48. Which one of the following antimicrobial agents would be MOST useful in the treatment of an infection caused by beta-Iactamase-producing staphylococci?
A.
B.
C.
D.
E.

49. Which of the following agents is NOT likely to reduce blood sugar in a patient with type II diabetes mellitus?
I. glucagon
II. pioglitazone
III. repaglinide
A.
B.
C.
D.
E.

50. Most antipsychotic drugs can be said to have which of the following actions?
A.
B.
C.
D.
E.

51. Beta carotene is considered to be a precursor for
A.
B.
C.
D.
E.

52. Clonidine may best be described as a (an)
A.
B.
C.
D.
E.

53. Which of the following is an active metabolite of primidone (Mysoline)?
I. acetylcholine
II. phenylethylmalonamide
III. phenobarbital
A.
B.
C.
D.
E.

54. Hypoparathyroidism is a disorder that would most logically be treated with
A.
B.
C.
D.
E.

55. Which of the following beta-adrenergic blocking agents is beta1-selective?
I. betaxolol (Betoptic)
II. metipranolol HCl (OptiPranolol)
III. timolol (Timoptic)
A.
B.
C.
D.
E.

56. Although classified as antibiotics, dactinomycin (Cosmegen) and plicamycin (Mithracin) are used in cancer chemotherapy because they have a (an)
A.
B.
C.
D.
E.

57. Nerves in the human body that transmit their impulses by releasing acetylcholine are known as ...... nerves.
A.
B.
C.
D.
E.

58. Simvastatin (Zocor) acts by
A.
B.
C.
D.
E.

59. Amrinone (Inocor) is a drug that produces
A.
B.
C.
D.
E.

60. Which of the following is (are) dopaminergic antiparkinson agents?
I. ropinirole (Requip)
II. pergolide (Permax)
III. procyclidine (Kemadrin)
A.
B.
C.
D.
E.