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Tofacitinib High Yield Notes

Tofacitinib High Yield Notes

How Tofacitinib Works?

Tofacitinib inhibits Janus kinase (JAK) enzymes, JAKs activate signal transducers and activators of transcription (STATs), which regulate gene expression and intracellular activity. Inhibition of JAKs prevents cytokine- or growth factor-mediated gene expression and intracellular activity of immune cells, reduces circulating CD16/56+ natural killer cells, serum IgG, IgM, IgA, and C-reactive protein, and increases B cells.

Adult Dosing

Psoriatic arthritis

Immediate release: 5mg twice
Extended release: 11mg once

Rheumatoid arthritis

Immediate release: 5mg twice
Extended release: 11mg once

Ulcerative colitis

Check out page 2 of the leaflet below.

For hepatic and renal patients, it’s preferred to reduce the dose to once daily, and stop it in case of sever hepatic impairment.

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