A 60-year-old male with angina comes to the emergency room with severe chest pain unresponsive to sublingual nitroglycerin. An EKG shows ST segment elevation in the anterolateral leads, and thrombolytic therapy is initiated. If streptokinase is given to this patient, it may produce thrombolysis after binding to which of the following proteins?
The parents of a 6-month-old child who was normal at birth bring her into the clinic. Since their emigration to the U.S. from Eastern Europe soon after her birth, the child has developed diminished responsiveness, progressive blindness and deafness, and recently, seizures. Serum levels of which of the following compounds would be expected to be decreased in both of the parents?
A 30-year-old veterinarian on a cattle ranch presents with a 1-to-2-month history of malaise, chills, drenching malodorous sweats, fatigue, and weakness. He has anorexia and has lost 15 pounds. He has intermittent fevers that range up to 103 F (39.4 C). He complains of visual blurring. A physical examination reveals mild lymphadenopathy, petechiae, and a cardiac murmur consistent with aortic insufficiency. What is the most likely etiologic agent?
A patient has a painful ulcer on the tip of his tongue. Which of the following cranial nerves carries the pain sensation he experiences?
5 mL of synovial fluid is aspirated from an inflamed knee joint. The fluid is yellow-white and cloudy and contains 200,000 WBC/mm3 (85% neutrophils). Needle-shaped, strongly negatively birefringent crystals are seen both within and outside neutrophils. These crystals most likely have which of the following compositions?
A particular association determines membership on the basis of members' IQ scores. Only those persons who have documented IQ scores at least 2 standard deviations above the mean on the Wechsler Adult Intelligence Scale (WAIS) are eligible for admission. Of a group of 200 people randomly selected from the population at large, how many would be eligible for membership to this society?
A 6-month-old boy is brought to the pediatrician by his parents, who are first cousins. This is their first child. Physical examination reveals a small, thin, lethargic infant with slightly misshapen long bones. His features are somewhat coarse. Joint movements are restricted, his corneas are clouded, and his gums are underdeveloped. His liver is not enlarged. Serum levels of acid hydrolases are found to be elevated. The child most likely has a defect in which of the following metabolic activities?
During embryological development, hematopoiesis occurs in different organs at different times. Which of the following are the correct organs, in the correct sequence, at which hematopoiesis occurs embryologically?
A 35-year-old woman notices a change in the appearance of a mole on her neck. Physical examination reveals that the lesion is an irregular, nodular, superficial mass with a variegated appearance. Biopsy demonstrates a primary malignant tumor. Which of the following factors is most predictive of the patient's long term prognosis?
An elderly woman with a history of multiple oral ulcers presents with flaccid bullae on her scalp, face, and trunk. Manual pressure on the skin produces separation of the upper layer of the epidermis, followed by eventual sloughing of the skin. The patient has been in relatively good health until recently, and denies taking any medications. A biopsy of one of the skin lesions reveals separation of epithelial cells above the basal layer. Autoantibodies to which of the following components would most likely be found in this patient?