A 32-year-old, blood type A positive male receives a kidney transplant from a blood type B positive female donor with whom he had a 6-antigen HLA match. Once the kidney is anastomosed to the man's vasculature, the transplant team immediately begins to observe swelling and interstitial hemorrhage. After the surgery, the patient developed fever and leukocytosis and produced no urine. Which of the following is the most likely explanation?
A 32-year-old pregnant woman is told by her physician to avoid taking aspirin. Use of aspirin is contraindicated, especially during the last part of pregnancy, because aspirin affects which of the following hematologic parameters?
Routine physical examination of a 55-year-old man demonstrates marked finger clubbing. Radiography of the hand shows new bone formation beneath the periosteum. With which of the following disorders is this finding most strongly associated?
An elderly woman with a history of multiple oral ulcers presents with flaccid bullae on her scalp, face, and trunk. Manual pressure on the skin produces separation of the upper layer of the epidermis, followed by eventual sloughing of the skin. The patient has been in relatively good health until recently, and denies taking any medications. A biopsy of one of the skin lesions reveals separation of epithelial cells above the basal layer. Autoantibodies to which of the following components would most likely be found in this patient?
A patient develops an acute febrile illness with shivers, nonproductive cough, and pleuritic chest pain. Five days later, he presents to the emergency room after abruptly having 'coughed up' nearly a cup of blood-stained sputum. Which of the following is most likely to be seen on chest x-ray?
A 2-year-old child presents to the pediatrician with hematuria. Examination reveals hypertension and an abdominal mass. A tumor is localized to the right kidney and biopsy reveals a stroma containing smooth and striated muscle, bone, cartilage, and fat, with areas of necrosis. The gene for this disorder has been localized to which of the following chromosomes?
In a genotypic male, the testes fail to develop, and do not secrete testosterone or MÃ¼llerian regression factor. Which of the following best describes the in utero reproductive system development of this individual?
A newborn boy does not pass meconium until 48 hours after his birth . Two weeks later his mother reports that he has not been passing stool regularly. Anorectal manometry reveals increased internal anal sphincter pressure on rectal distention with a balloon. Radiographic studies revea l massive dilation of the colon proximal to the rectum. This indicates a developmental abnormality in which of the following embryonic tissues?
A 15-year-old boy is evaluated by a clinician for failure to develop normal male secondary sexual characteristics. Physical examination reveals small testes, a small penis, and gynecomastia. The boy has had some difficulties in school, and the parents say that the school psychometrist said he had an IQ of 90. This patient's condition is most likely to be related to which of the following?
A young man recently died during surgery
under general anesthesia. Symptoms prior to his death included muscle spasms,
hyperthermia, acidosis, and cardiac arrest. His family history is significant
for his father dying under similar conditions and an aunt having survived the
same complications during a hip replacement surgery. He is survived by his
wife, a son, and a daughter. DNA has been isolated from family members and a
Southern blot of restriction fragments from a specific region of chromosome
19 reveals the following pattern: Which of the following conclusions can
reasonably be drawn from these data?